Scorer: Cuadrado 83′, Lukaku (PEN) 90+4′
Both teams made a host of changes for Tuesday’s third Derby d’Italia of the season as Simone Inzaghi’s reigning holders started the stronger.
Lautaro Martínez sounded their first warning shot in the 10th minute when he met Alessandro Bastoni’s searching left-sided cross but sent his effort looping just over.
The Nerazzurri continued to turn the screw as Federico Dimarco produced a 25-yard free kick which forced Mattia Perin into a smart stop.
Juventus’ goalkeeper remained the busier at the Allianz Stadium after Edin Džeko teed up Marcelo Brozović shortly after the half-hour mark, only for a superb save to deny him.
Massimiliano Allegri’s side delivered a response as Nicolò Fagioli exchanged passes with Dušan Vlahović before picking out the striker for a header that Samir Handanović was able to collect.
But the hosts had Gleison Bremer to thank for preventing Inter from breaking the deadlock with a timely interception to prevent Dimarco benefiting from Henrikh Mkhitaryan’s defence-splitting pass.
Vlahović attempted to build on the attacking impetus Juve showed in the opening 45 minutes but met Fagioli’s delivery with an awkward effort.
Filip Kostić went marginally closer when letting fly shortly before the hour mark as his shot whistled over Handanović’s crossbar.
Inter almost took the lead after Dimarco set Mkhitaryan clear as the Armenia international dummied Manuel Locatelli and dragged a shot just wide of Perin’s right-hand post.
Substitute Arkadiusz Milik missed a gilt-edged chance during the game’s final quarter when Juan Cuadrado threaded a ball across the face of goal which he failed to connect with.
Cuadrado appeared to have Juve took a slender advantage into the return leg at San Siro with a sweeping close-range finish just seven minutes from time.
Yet Inter snatched an equaliser from the penalty spot in the fourth minute of added time after a handball by Bremer before his overenthusiastic celebration delivered a second booking, which rules him out of the return leg.
- Tempers continued to flare after the final whistle as Cuadrado and Handanović also received their retrospective marching orders with straight red cards.